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SPION targeting of ADSCs in diabetic ED



Stem cell therapy is a promising new frontier for the treatment of diabetic erectile dysfunction. However, inadequate cell homing to damaged sites has limited their efficacy. In the current study, we labelled adipose tissue-derived stem cells (ADSCs) with a conventional magnetic resonance imaging contrast agent, superparamagnetic iron oxide nanoparticles (SPIONs), and demonstrated that application of an external magnetic field could improve the in vivo homing efficiency of ADSCs to the corpus cavernosum region and contribute to the improvement in erectile function of diabetic rats. Besides, our further research suggested that the paracrine effect of ADSCs appeared to play the major role in functional and structural recovery. In conclusion, our study provides evidence that magnetic field-guided ADSC therapy is an efficient approach for diabetic ED therapy. Please refer to pages 425-432 by Zhu et al. for details. (Artwork is displayed by Xiang Chen)

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