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SSC: a tool to know spermatogenesis



Spermatogonial stem cells (SSCs) are required to maintain the whole spermatogenesis throughout the reproductive life of mammals. The identification of exogenous factors that contributed to continuous proliferation of SSCs in vitro constructs the foundation to investigate the basic characters of SSCs. Indeed, SSCs culture and transplantation provide a powerful model to clarify the mechanisms regulating SSC self-renewal and spermatogenesis, and elicit new insights into the treatment of male infertility. In this study, by using cultured mouse neonatal testes and SSCs, we identified a new factor, Strawberry Notch 1(SBNO1), which could maintain SSCs by promoting the noncanonical Wnt pathway. Please refer to pages 345–350.

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