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Sperm DNA damage and IVF outcome

Sperm DNA damage is recognized as an important biomarker of male infertility. The aim of the present study was to examine the relationship between sperm DNA damage and IVF outcomes. The sperm chromatin dispersion (SCD) test was employed to assess sperm DNA damage in semen and motile spermatozoa harvested by combined density gradient centrifugation and swim-up in semen samples. Couples were divided into two groups according to pregnancy or not. The sperm DNA damage was significantly different between two groups and was negatively correlated with IVF outcomes. Logistic regression analysis confirmed that it was an independent predictor for achieving clinical pregnancy. Following IVF, the results showed that embryo quality, blastocyst formation, implantation and pregnancy rates decreased with the increase of sperm DNA damage, but the fertilization rate was not affected. Sperm DNA damage as measured by the SCD appears useful for predicting the clinical pregnancy rate following IVF. Please refer to pages 75-79 by Zheng et al. for details. (Artwork is displayed by Xiang Chen)

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