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SPARC changes in prostate cancer

Secreted protein acidic and rich in cysteines (SPARC) is a matricellular protein highly expressed in bone tissue that has been described as a chemoattractant factor promoting the arrival of prostate cancer cells to the bone marrow. However, there is no consensus regarding its contribution during the early stages of tumor progression. In this cover, we show that the knockdown of SPARC in prostate cancer cells changes the fusiform shape, typical of mesenchymal cells, to a more polygonal and larger one, which is consistent with an epithelial morphology. In our work, we found that SPARC induces several other changes in the molecular, morphological and functional characteristics of prostate cancer cells, associated with the epithelialmesenchymal transition program. Please refer to pages 557–564.

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