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PELP1 levels up pull sperm down



Standard semen parameters may no longer be plausible sperm biomarkers. For this reason, other, such as the expression patterns of sperm RNAs and protein, need to be evaluated instead. This study aimed to gain insight into molecular sperm defects which may lead to conception failure. The assessment of PELP1 may be a time-saving method used to obtain information about sperm quality. The presence of mRNA, protein, and cellular localization of PELP1 in ejaculated spermatozoa was confirmed. Moreover, flow cytometry analysis showed that the percentage of sperm cells stained with PELP1 antibody is negatively correlated with increasing sperm quality. The results suggest that PEPL1 may as well be utilized as an indicator of sperm quality and also an additional biomarker useful in the evaluation of male infertility. Please refer to Pages 425-431 by Skibinska et al. for details.( Artwork is displayed by Xiang Chen)

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